Case Report: A diabetic ketoacidosis in adolescents complicated with rhino-orbital-cerebral mucormycosis
-
By
-
Jinxin Tang
-
Qishu Hou
-
Jifeng Ye
-
Yueyue Weng
-
July 14, 2026
Clinical Scorecard: Clinical Case Study: Adolescent Diabetic Ketoacidosis Complicated by Rhino-Orbital-Cerebral Mucormycosis
At a Glance
| Category | Detail |
|---|
| Condition | Rhino-orbital-cerebral mucormycosis (ROCM) |
| Key Mechanisms | Infection caused by Mucorales fungi, leading to rapid progression and high mortality. |
| Target Population | Adolescents with type 1 diabetes mellitus (T1DM) |
| Care Setting | Hospitalized care for severe fungal infections |
Key Highlights
- ROCM is an aggressive infection with high mortality and disability rates.
- Early symptoms can be non-specific, leading to misdiagnosis.
- Multidisciplinary collaboration is crucial for effective management.
- Individualized antifungal regimens are necessary based on patient condition.
- Clinical pharmacists play a key role in treatment optimization and monitoring.
Guideline-Based Recommendations
Diagnosis
- Utilize multi-modal diagnostic approaches including mNGS and tissue biopsy.
Management
- Initial treatment with liposomal amphotericin B and nasal endoscopic debridement.
Monitoring & Follow-up
- Continuous monitoring for drug toxicity and adverse reactions.
Risks
- High risk of rapid disease progression and complications in T1DM patients.
Patient & Prescribing Data
14-year-old female with T1DM and DKA.
Treatment adjusted to include oral isavuconazole and intranasal amphotericin B deoxycholate after initial therapy.
Clinical Best Practices
- Monitor for non-specific prodromal symptoms in at-risk populations.
- Implement early and aggressive treatment strategies for ROCM.
- Engage clinical pharmacists in the management of severe fungal infections.
Related Resources & Content
