Clinical and Imaging Characteristics of Severe Mpox: A Case Study Involving 16 Patients from Beijing, China
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By
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Fuchun Wang
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Yuan Fang
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Zhongkai Zhou
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Hao Liu
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Jiahao Ji
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Lin Jia
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Han Jia
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Luyao Zheng
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Wen Wang
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Caiping Guo
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Chunwang Yuan
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Yue Yin
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Juming Ma
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Hongjun Li
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Budong Chen
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Junyi Duan
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Tao Huang
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Guanghui Zhang
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Taiyi Jiang
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Tong Zhang
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Wei Wang
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January 20, 2026
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Clinical Scorecard: Clinical and Imaging Characteristics of Severe Mpox: A Case Study Involving 16 Patients from Beijing, China
At a Glance
| Category | Detail |
|---|
| Condition | Severe Mpox (Monkeypox) |
| Key Mechanisms | Zoonotic viral infection caused by MPXV, primarily transmitted through direct contact with lesions or bodily fluids. |
| Target Population | Individuals diagnosed with severe mpox, particularly those co-infected with HIV. |
| Care Setting | Single-center retrospective case series at Beijing Youan Hospital. |
Key Highlights
- Severe mpox cases often present with disseminated infections affecting multiple organs.
- High prevalence of severe cases among men who have sex with men (MSM) and individuals co-infected with HIV.
- Imaging plays a crucial role in diagnosing and monitoring severe mpox complications.
Guideline-Based Recommendations
Diagnosis
- Confirmed by positive PCR test for MPXV with Ct value < 40.
Management
- Severe cases may require surgical intervention for necrotic lesions.
Monitoring & Follow-up
- Regular imaging assessments to evaluate complications and disease progression.
Risks
- Increased mortality rate associated with severe mpox, especially in immunocompromised individuals.
Patient & Prescribing Data
16 patients with severe mpox co-infected with HIV.
Management strategies should consider the presence of HIV and associated complications.
Clinical Best Practices
- Early diagnosis through PCR testing is critical for effective management.
- Monitor for complications such as secondary infections and organ involvement.
- Consider the patient's immune status when assessing severity and treatment options.
References
