Targeted replacement of human γδ TCR in mice enhances antigen-specific B cell immunity
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By
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Husheem Michael
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Michael Pitre
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Gene W. Weng
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Mikaela M. Vallas
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Ellen Chen
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Paul Sheiffele
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Wei Weng
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June 17, 2026
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Clinical Scorecard: Enhanced Antigen-Specific B Cell Responses in Mice with Human γδ T Cell Receptor Replacement
At a Glance
| Category | Detail |
|---|
| Condition | Immune response modulation |
| Key Mechanisms | Human γδ T cells enhance B cell activity through direct interactions and cytokine signaling. |
| Target Population | Mice with humanized γδ T cell receptors |
| Care Setting | Preclinical research |
Key Highlights
- γδ HuTCR-T1 mice show increased antigen-specific antibody-secreting cells (ASCs).
- Elevated serum levels of antigen-specific IgG, IgA, and IgE in γδ HuTCR-T1 mice.
- Distinct cytokine profile with increased IL-4, IL-6, IL-10, IL-17, TGFβ, IFNγ, and TNFα.
- Serum anti-ANA antibodies remained below detection threshold.
- Study advances understanding of γδ T cells in immune homeostasis.
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Not applicable; study conducted in mice.
Humanized γδ TCR mice can be used to study B cell immune responses.
Clinical Best Practices
- Utilize humanized mouse models for studying human immune responses.
- Investigate γδ T cell interactions with B cells for potential immunotherapy applications.
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