S-GRAS score and the complementary prognostic value of neutrophil-to-lymphocyte ratio in adrenocortical carcinoma: evidence for a synergistic interaction - Scorecard - MDSpire

S-GRAS score and the complementary prognostic value of neutrophil-to-lymphocyte ratio in adrenocortical carcinoma: evidence for a synergistic interaction

  • By

  • Erik Bényei

  • Gergely Huszty

  • András Laki

  • Zsuzsanna Jakab

  • Gergely Kiss

  • Attila Kristóf Kovács

  • Katalin Borka

  • Andrea Uhlyarik

  • Katalin Eitler

  • Peter Igaz

  • Judit Tőke

  • Miklós Tóth

  • June 8, 2026

  • 0 min

Share

Clinical Scorecard: Evaluating the Prognostic Significance of the S-GRAS Score and Neutrophil-to-Lymphocyte Ratio in Adrenocortical Carcinoma: Insights into Their Combined Effect

At a Glance

CategoryDetail
Condition
Key MechanismsS-GRAS score, inflammation-based scores (NLR, PLR)
Target Population
Care Setting

Key Highlights

  • S-GRAS score demonstrated superior discriminative ability (C-index=0.765) compared to its components.
  • NLR identified as a significant predictor of mortality (HR = 3.1; p=0.008).
  • Joint application of S-GRAS and NLR showed superior prognostic discrimination (C-index=0.822).
  • Synergistic interaction between S-GRAS and NLR was significant (HR = 1.177, p=0.009).
  • External validation confirms the prognostic robustness of the S-GRAS score.

Guideline-Based Recommendations

Diagnosis

    Management

    • Management strategies based on S-GRAS score include postoperative adjuvant treatment with mitotane alone or combined with cytotoxic drugs.
    • Consider NLR levels when determining treatment plans.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Adult patients with histologically confirmed ACC treated between 2000 and 2023.

        Combination of S-GRAS and NLR provides complementary predictive value.

        Clinical Best Practices

        • Utilize S-GRAS score for risk stratification in ACC patients.
        • Incorporate NLR as an additional prognostic marker.
        • Monitor PLR alongside NLR for comprehensive prognostic evaluation.

        Related Resources & Content

        Original Source(s)

        S-GRAS score and the complementary prognostic value of neutrophil-to-lymphocyte ratio in adrenocortical carcinoma: evidence for a synergistic interaction

        • by Erik Bényei, Gergely Huszty, András Laki, Zsuzsanna Jakab, Gergely Kiss, Attila Kristóf Kovács, Katalin Borka, Andrea Uhlyarik, Katalin Eitler, Peter Igaz, Judit Tőke, Miklós Tóth

        • June 8, 2026

        Related Content

        Training on PD-L1 scoring in non-small cell lung cancer with high intra- and inter-reader agreement: results of a worldwide microscopic/digital image-based training of 751 pathologists

        A study on risk prediction of decline in self-care ability one month after discharge in postoperative colorectal cancer patients based on routine clinical indicators

        Case Report: Successful conversion surgery following chemo-antiangiogenic therapy in a lung adenocarcinoma patient with active rheumatoid arthritis and rare EGFR mutation after immunotherapy-triggered flare