Neuroimmune-driven abrupt neuropsychiatric symptoms in children: preventing pathological fear consolidation
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By
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Sun Young Yum
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Sehee Hwang
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Michael Y. Hwang
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June 5, 2026
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Clinical Scorecard: Neuroimmune Factors in Sudden Neuropsychiatric Manifestations in Children: Strategies to Mitigate Pathological Fear Development
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Neuroimmune processes causing brainwide disruptions and unconditioned alarm, leading to acute fear states. |
| Target Population | |
| Care Setting | |
Key Highlights
- Fear Rebalance Therapy (FRT) is proposed as a framework for addressing acute fear in PANS, requiring empirical validation.
Guideline-Based Recommendations
Diagnosis
Management
- Implement anti-inflammatory treatments promptly to address neuroimmune triggers, such as corticosteroids or intravenous immunoglobulin.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Children with acute-onset neuropsychiatric symptoms.
Focus on managing neuroimmune responses while addressing psychological aspects of fear.
Clinical Best Practices
- Integrate psychological interventions actively during the acute crisis phase, focusing on co-regulation and safety learning.
Related Resources & Content
