RNA binding protein YWHAZ mediates specific mRNA translation and regulates cell proliferation and apoptosis in diabetic foot ulcer
By
Tianjian Zha
Junjie Yao
Hao Wang
Qiang Cao
Jian Zhang
Zhao Chen
Jie Wang
May 7, 2026
Clinical Scorecard: YWHAZ RNA-Binding Protein Influences mRNA Translation and Modulates Cell Growth and Apoptosis in Diabetic Foot Ulcers
At a Glance
Category Detail
Condition Diabetic Foot Ulcer (DFU) Key Mechanisms YWHAZ regulates post-transcriptional gene expression and influences cell proliferation, migration, and apoptosis. Target Population Individuals with diabetes experiencing non-healing foot ulcers. Care Setting Clinical settings managing diabetic complications.
Key Highlights
YWHAZ is upregulated in DFU tissues and plays a critical role in keratinocyte functionality. Knockdown of YWHAZ promotes cell proliferation and migration while suppressing apoptosis. RNA-seq analysis identified 1,072 differentially expressed genes associated with YWHAZ. YWHAZ binds to GC-rich motifs and associates with numerous mRNAs in DFU tissues. SREBF1, a gene linked to type 2 diabetes risk, is positively correlated with YWHAZ expression. Guideline-Based Recommendations
Diagnosis
Utilize RNA sequencing to identify gene expression profiles in DFU tissues. Management
Consider targeting YWHAZ expression as a therapeutic approach in DFU treatment. Monitoring & Follow-up
Monitor gene expression changes in response to therapeutic interventions targeting YWHAZ. Risks
Elevated YWHAZ levels may contribute to impaired healing and increased risk of complications in DFU. Patient & Prescribing Data
Patients with diabetes and chronic non-healing foot ulcers.
Targeting YWHAZ may enhance keratinocyte function and improve healing outcomes.
Clinical Best Practices
Incorporate RNA-binding protein analysis in the evaluation of DFU. Utilize multidisciplinary approaches for managing DFU, focusing on molecular targets like YWHAZ. Related Resources & Content
