Integrated meta-analysis, network pharmacology and experimental validation to explore the mechanism of traditional Chinese medicine against neonatal pneumonia: focus on naringenin/MAPK1 - Scorecard - MDSpire
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Integrated meta-analysis, network pharmacology and experimental validation to explore the mechanism of traditional Chinese medicine against neonatal pneumonia: focus on naringenin/MAPK1
Clinical Scorecard: Comprehensive Meta-Analysis, Network Pharmacology, and Experimental Assessment of Traditional Chinese Medicine's Mechanism Against Neonatal Pneumonia: Emphasis on Naringenin and MAPK1
At a Glance
Category
Detail
Condition
Key Mechanisms
Involvement of MAPK1 and inflammatory signaling pathways, with naringenin as a key active component targeting MAPK1.
Target Population
Care Setting
Key Highlights
Significant clinical efficacy of TCM bath composed of specific herbs, particularly in reducing inflammation.
Identification of MAPK1 as a hub gene involved in inflammatory pathways.
Naringenin shows strong binding affinity to MAPK1, enhancing therapeutic potential.
In vitro studies demonstrate enhanced cell viability and reduced inflammatory cytokines with naringenin and MAPK1 knockdown.
Guideline-Based Recommendations
Diagnosis
Management
Utilize broad-spectrum antibiotics as first-line therapies alongside TCM, including specific herbal formulations.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Combination of TCM, such as specific herbal treatments, and Western medicine may enhance treatment efficacy.
Clinical Best Practices
Integrate TCM with conventional therapies for comprehensive care, supported by clinical evidence.
Focus on multi-targeted approaches to manage neonatal pneumonia, utilizing both TCM and Western medicine.
