The efficacy and safety of Femoston combined with Baoqing granules for kidney Yin deficiency in perimenopausal women: a randomized, double-blind, placebo-controlled trial - Scorecard - MDSpire
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The efficacy and safety of Femoston combined with Baoqing granules for kidney Yin deficiency in perimenopausal women: a randomized, double-blind, placebo-controlled trial
Clinical Scorecard: Evaluating the Safety and Effectiveness of Femoston in Combination with Baoqing Granules for Treating Kidney Yin Deficiency in Perimenopausal Women
At a Glance
Category
Detail
Condition
Perimenopausal symptoms associated with kidney Yin deficiency
Key Mechanisms
Combination of estrogen replacement (Femoston) with kidney Yin nourishing herbal formula (Baoqing Granules) targeting multidimensional symptoms
Target Population
Perimenopausal women diagnosed with kidney Yin deficiency syndrome
Care Setting
Outpatient clinical setting with hormone therapy and complementary herbal treatment
Key Highlights
Femoston plus Baoqing Granules (BQG) showed greater short-term improvement in menopausal symptom scores compared to Femoston plus placebo.
BQG adjunct therapy improved quality of life, sleep quality, and psychological symptoms with acceptable safety and tolerability.
No significant adverse effects on liver or kidney function were observed; only one mild adverse event reported.
Guideline-Based Recommendations
Diagnosis
Assess perimenopausal symptoms using Modified Kupperman Menopausal Index and TCM syndrome scoring for kidney Yin deficiency.
Evaluate quality of life and psychological status with MENQOL, PSQI, SAS, and SDS scales.
Management
Consider Femoston as standard hormone replacement therapy for symptom relief.
Adjunctive use of Baoqing Granules may provide additional benefits in symptom control and quality of life.
Monitor hormone and lipid profiles to assess treatment effects, especially in postmenopausal women.
Monitoring & Follow-up
Regularly monitor hepatic and renal function during combined therapy.
Observe for adverse events and symptom changes during treatment and follow-up.
Risks
Long-term safety of combined Femoston and BQG therapy remains to be established.
Potential risks associated with hormone therapy should be considered, including cancer and thromboembolism risks.
Patient & Prescribing Data
Perimenopausal women with kidney Yin deficiency syndrome undergoing hormone therapy
Short-term adjunctive use of BQG with Femoston improves multidimensional symptoms and is well tolerated; longer-term data needed.
Clinical Best Practices
Use validated symptom and quality of life scales to guide treatment decisions and monitor response.
Incorporate TCM syndrome differentiation to tailor complementary herbal therapy.
Ensure safety monitoring including liver and kidney function tests during combined treatment.
Educate patients on potential benefits and limitations of combined hormone and herbal therapy.
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