Link Between Serum Uric Acid to HDL Cholesterol Ratio and Overall as Well as Cardiovascular Mortality in Gout Patients
By
Xiaolin Lou
Rubing Guo
Yongtong Cao
Wei Zhao
November 19, 2025
Clinical Scorecard: Link Between Serum Uric Acid to HDL Cholesterol Ratio and Overall as Well as Cardiovascular Mortality in Gout Patients
At a Glance
Category Detail
Condition Gout Key Mechanisms Uric acid promotes atherosclerosis; HDL cholesterol provides cardioprotection. Target Population Adults diagnosed with gout, particularly those with metabolic dysfunction. Care Setting Outpatient settings utilizing NHANES data.
Key Highlights
Gout is the most prevalent inflammatory arthritis in men and a leading cause in elderly women. Uric acid to HDL cholesterol ratio (UHR) is a novel biomarker for assessing cardiovascular risk. Higher UHR is linked to increased cardiovascular mortality in gout patients. Systemic inflammation from gout may accelerate cardiovascular disease progression. Timely intervention for metabolic dysfunction is crucial for optimizing therapeutic outcomes. Guideline-Based Recommendations
Diagnosis
Gout diagnosis confirmed via self-reported questionnaire. Management
Monitor uric acid levels and HDL cholesterol in gout patients. Monitoring & Follow-up
Regular follow-up on cardiovascular health and metabolic status. Risks
Increased risk of all-cause and cardiovascular mortality associated with high UHR. Patient & Prescribing Data
Adults aged 20 and older diagnosed with gout.
Focus on managing uric acid levels and monitoring cardiovascular health.
Clinical Best Practices
Utilize UHR as a composite biomarker for cardiovascular risk assessment. Incorporate lifestyle modifications and pharmacotherapy to manage uric acid levels. Conduct regular cardiovascular risk evaluations in gout patients. Related Resources & Content
