Peripheral retinal degenerations: multimodal imaging–guided risk stratification and clinical decision-making

Category	Detail
Condition	Peripheral Retinal Degenerations (PRD)
Key Mechanisms	Posterior vitreous detachment (PVD) as a key biomechanical event linking PRD with retinal tears (RT) and rhegmatogenous retinal detachment (RRD).
Target Population	General population with peripheral retinal alterations, particularly those at risk for RT and RRD.
Care Setting	Ophthalmology clinics utilizing advanced imaging techniques.

PRD can be stratified into low, intermediate, and high-risk categories based on clinical and imaging features.
PVD is crucial in the development of RT and RRD, especially during acute symptomatic stages.
Selective prophylactic laser photocoagulation is recommended for symptomatic RT and confirmed tractional instability.
Routine treatment of asymptomatic low-risk PRD is not justified.
AI-assisted decision support may standardize risk interpretation in clinical practice.

Utilize multimodal imaging techniques such as ultra-widefield (UWF) imaging and swept-source OCT (SS-OCT) for assessment.

Implement selective prophylactic interventions for high-risk lesions and symptomatic cases.

Potential for retinal tears and detachment in high-risk PRD, particularly with PVD.

Patients with peripheral retinal degenerations, particularly those with symptomatic or high-risk features.

Intervention should be individualized based on imaging findings and clinical assessment.

Integrate clinical assessment with multimodal imaging for PRD management.
Differentiate between benign and tractionally unstable lesions to guide treatment decisions.
Utilize AI-assisted tools to enhance risk stratification and decision-making.