Exploring the Gut-Lung Connection in Pediatric Asthma: From Early Microbial Influences to Tailored Microbiome-Based Therapies—A Comprehensive Review - Scorecard - MDSpire

Exploring the Gut-Lung Connection in Pediatric Asthma: From Early Microbial Influences to Tailored Microbiome-Based Therapies—A Comprehensive Review

  • By

  • Miaojun Mo

  • Linlin Chen

  • Yi Wang

  • Xinyu Lin

  • Haiting Li

  • Binbin Chen

  • Junhui Yuan

  • Enfu Tao

  • April 22, 2026

  • 0 min

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Clinical Scorecard: Exploring the Gut-Lung Connection in Pediatric Asthma: From Early Microbial Influences to Tailored Microbiome-Based Therapies—A Comprehensive Review

At a Glance

CategoryDetail
ConditionPediatric Asthma
Key MechanismsGut-lung axis, microbial metabolites, immune homeostasis
Target PopulationChildren with asthma
Care SettingPediatric healthcare

Key Highlights

  • Disruptions in microbial-immune crosstalk during early life shape asthma susceptibility.
  • Microbial metabolites like short-chain fatty acids play a crucial role in immune regulation.
  • Emerging microbiome-targeted interventions show therapeutic promise for asthma management.

Guideline-Based Recommendations

Diagnosis

  • Utilize multi-omics profiling for personalized risk prediction and endotype identification.

Management

  • Consider strain-specific probiotics, prebiotics, and fecal microbiota transplantation as potential therapies.

Monitoring & Follow-up

  • Monitor microbial signatures to correlate with specific asthma endotypes.

Risks

  • Dysbiosis can lead to compromised epithelial barrier integrity and pro-allergic immune responses.

Patient & Prescribing Data

Children at risk for or diagnosed with asthma

Microbiome-informed precision medicine may improve treatment outcomes.

Clinical Best Practices

  • Integrate early-life environmental exposures in asthma risk assessments.
  • Adopt a multi-omics approach to understand individual patient profiles.

References

Original Source(s)

Exploring the Gut-Lung Connection in Pediatric Asthma: From Early Microbial Influences to Tailored Microbiome-Based Therapies—A Comprehensive Review

  • by Miaojun Mo, Linlin Chen, Yi Wang, Xinyu Lin, Haiting Li, Binbin Chen, Junhui Yuan, Enfu Tao

  • April 22, 2026

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