Ginseng-mulberry (medicine-food homologous) pair mitigates cadmium-induced anxiety: a clinical proteomics-guided network pharmacology with rat validation - Scorecard - MDSpire
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Ginseng-mulberry (medicine-food homologous) pair mitigates cadmium-induced anxiety: a clinical proteomics-guided network pharmacology with rat validation
Clinical Scorecard: Ginseng and Mulberry Combination Reduces Anxiety Induced by Cadmium: Insights from Clinical Proteomics and Network Pharmacology with Rat Model Confirmation
At a Glance
Category
Detail
Condition
Cadmium-induced anxiety
Key Mechanisms
Involvement of AKT1, PTGS2, and HSP90AA1 in neurotoxicity and anxiety modulation
Target Population
Adults exposed to cadmium with anxiety symptoms
Care Setting
Clinical and experimental research settings
Key Highlights
Identification of 120 differentially expressed proteins associated with anxiety in cadmium-exposed individuals
Ginseng and mulberry leaf prioritized as therapeutic candidates through network pharmacology
Decoction reverses anxiety-like behavior and neurovascular pathology in rat models
Guideline-Based Recommendations
Diagnosis
Anxiety status ascertained using the 14-item Hamilton Anxiety Rating Scale (HAMA-14)
Management
Consider ginseng and mulberry leaf decoction for cadmium-induced anxiety
Monitoring & Follow-up
Evaluate changes in anxiety symptoms and neurobehavioral outcomes post-treatment
Risks
Potential neurotoxic effects of chronic cadmium exposure
Patient & Prescribing Data
Adults from cadmium-contaminated regions with anxiety
Ginseng and mulberry leaf decoction may mitigate anxiety symptoms and associated neurotoxicity
Clinical Best Practices
Utilize multi-target interventions for complex exposure-related anxiety
Incorporate proteomics and network pharmacology in therapeutic discovery
