Case report: Pediatric vascular Behçet’s disease with prominent arterial involvement: a case series of five patients
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By
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Baoping He
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Hengai Zhang
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Qiang Ma
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Yang Yang
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Baiyu Chen
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Lian Wang
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Jianming Lai
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June 24, 2026
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Clinical Scorecard: Pediatric Vascular Behçet’s Disease with Significant Arterial Involvement: A Case Series of Five Female Patients
At a Glance
| Category | Detail |
|---|
| Condition | Pediatric Vascular Behçet’s Disease |
| Key Mechanisms | Vascular inflammation leading to arterial involvement |
| Target Population | Pediatric patients (ages 10-15 years) |
| Care Setting | Pediatric rheumatology and vascular imaging |
Key Highlights
- All patients exhibited arterial involvement with mucocutaneous and systemic symptoms.
- Combination therapy with glucocorticoids and immunosuppressants showed favorable outcomes.
- Elevated inflammatory markers were present in all cases.
- Significant clinical improvement and resolution of vascular lesions were observed during follow-up.
- Proactive vascular screening is critical for early diagnosis and intervention.
Guideline-Based Recommendations
Diagnosis
- Utilize the 2015 Pediatric Behçet’s Disease diagnostic criteria.
Management
- Initiate glucocorticoids at 1-2 mg/kg/day, with individualized combination regimens including immunosuppressants and/or anti-TNF-α agents.
Monitoring & Follow-up
- Conduct systematic vascular screening with Doppler ultrasound and CTA.
Risks
- Potential for severe vascular complications and gastrointestinal issues.
Patient & Prescribing Data
Five female pediatric patients with VBD.
All patients received glucocorticoids, with some requiring aggressive methylprednisolone pulse therapy.
Clinical Best Practices
- Early diagnosis and proactive vascular screening are essential.
- Combination therapy should be tailored to individual patient needs.
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