Pediatric Vascular Behçet’s Disease with Significant Arterial Involvement: A Case Series of Five Female Patients
By
Baoping He
Hengai Zhang
Qiang Ma
Yang Yang
Baiyu Chen
Lian Wang
Jianming Lai
June 24, 2026
Clinical Scorecard: Pediatric Vascular Behçet’s Disease with Significant Arterial Involvement: A Case Series of Five Female Patients
At a Glance
Category Detail
Condition Pediatric Vascular Behçet’s Disease Key Mechanisms Vascular inflammation leading to arterial involvement Target Population Pediatric patients (ages 10-15 years) Care Setting Pediatric rheumatology and vascular imaging
Key Highlights
All patients exhibited arterial involvement with mucocutaneous and systemic symptoms. Combination therapy with glucocorticoids and immunosuppressants showed favorable outcomes. Elevated inflammatory markers were present in all cases. Significant clinical improvement and resolution of vascular lesions were observed during follow-up. Proactive vascular screening is critical for early diagnosis and intervention. Guideline-Based Recommendations
Diagnosis
Utilize the 2015 Pediatric Behçet’s Disease diagnostic criteria. Management
Initiate glucocorticoids at 1-2 mg/kg/day, with individualized combination regimens including immunosuppressants and/or anti-TNF-α agents. Monitoring & Follow-up
Conduct systematic vascular screening with Doppler ultrasound and CTA. Risks
Potential for severe vascular complications and gastrointestinal issues. Patient & Prescribing Data
Five female pediatric patients with VBD.
All patients received glucocorticoids, with some requiring aggressive methylprednisolone pulse therapy.
Clinical Best Practices
Early diagnosis and proactive vascular screening are essential. Combination therapy should be tailored to individual patient needs. Related Resources & Content
