Keloids exhibit invasive growth beyond original wound margins and high recurrence rates, exacerbated by mechanical forces.
Pathogenesis involves mechanical forces and inflammatory responses creating a positive feedback loop.
Current management includes surgery, radiotherapy, and intralesional injections, but faces challenges, including high recurrence rates.
Guideline-Based Recommendations
Diagnosis
Management
Multimodal regimens including surgical excision, radiotherapy, and pharmacologic injections, with emerging therapies targeting inflammatory pathways.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Emerging therapies targeting inflammatory pathways and mechanomodulation, relevant for patients with chronic inflammatory fibroproliferative disorders.
Clinical Best Practices
Consider integrated approaches addressing both mechanical and inflammatory factors, including specific tension-reduction strategies.
Two patients presented months after minimally invasive facial procedures with persistent findings that ultimately revealed retained foreign bodies, according to a recent case series.
