A Rare Case of Primary Angiomyofibroma of Soft Tissue in the Small Intestine Complicated by Intussusception: Case Report and Literature Review

Category	Detail
Condition	Angiomyofibroma of soft tissue (AFST)
Key Mechanisms	Benign mesenchymal neoplasm characterized by spindle cells and a branching vascular network, primarily found in soft tissues.
Target Population	Primarily affects adults, with a peak incidence in the 60s; rare in the gastrointestinal tract.
Care Setting	Emergency department and surgical intervention.

AFST is a rare tumor, with primary occurrence in the small intestine being exceedingly uncommon.
Histological features include bland spindle cells and a prominent vascular network.
The tumor can lead to mechanical complications such as intussusception due to mass effect.
Immunohistochemical markers include CD68 positivity and negative for a comprehensive panel of other markers.
Molecular features, including NCOA2 gene rearrangements, are significant for diagnosis.
Complete surgical excision is advised due to the risk of local recurrence.

Histological examination and immunohistochemistry are essential for diagnosis.
Molecular techniques like FISH or NGS are recommended for definitive confirmation.

Adults, with a noted female predilection.

Postoperative care includes anti-inflammatory and anti-infective measures to prevent complications.

Ensure thorough histological and immunohistochemical evaluation for accurate diagnosis.
Consider molecular genetic studies for definitive diagnosis in ambiguous cases.
Monitor for complications post-surgery, including signs of recurrence.

Clinical Scorecard: A Rare Case of Primary Angiomyofibroma of Soft Tissue in the Small Intestine Complicated by Intussusception: Case Report and Literature Review