A higher monocyte-to-lymphocyte ratio is correlated with impaired glomerular function and adverse cardiac remodeling in elderly patients with atrial fibrillation: a retrospective study - Scorecard - MDSpire
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A higher monocyte-to-lymphocyte ratio is correlated with impaired glomerular function and adverse cardiac remodeling in elderly patients with atrial fibrillation: a retrospective study
Clinical Scorecard: Elevated Monocyte-to-Lymphocyte Ratio Linked to Diminished Glomerular Function and Negative Cardiac Remodeling in Older Adults with Atrial Fibrillation: A Retrospective Analysis
At a Glance
Category
Detail
Condition
Atrial Fibrillation
Key Mechanisms
Elevated monocyte-to-lymphocyte ratio (MLR) associated with adverse cardiac remodeling and decreased glomerular function.
Target Population
Elderly patients (aged ≥ 65 years) with atrial fibrillation.
Care Setting
Inpatient department of a medical care center.
Key Highlights
High MLR (> 0.460) linked to decreased estimated glomerular filtration rate (eGFR).
High MLR associated with lower plasma albumin levels.
Adverse cardiac remodeling observed in patients with high MLR.
Study involved 1,154 elderly hospitalized patients with AF.
MLR calculated from white blood cell counts.
Guideline-Based Recommendations
Diagnosis
Patients with AF should be assessed for inflammatory markers, including MLR.
Management
Monitor MLR as a potential indicator of cardiac remodeling in elderly AF patients.
Monitoring & Follow-up
Regular assessment of eGFR and plasma albumin levels in patients with elevated MLR.
Risks
Increased cardiovascular mortality associated with high MLR in AF patients.
Patient & Prescribing Data
Elderly patients with non-valvular atrial fibrillation.
Anticoagulant treatment may reduce thromboembolism-related mortality but does not eliminate cardiovascular mortality risk.
Clinical Best Practices
Incorporate MLR assessment in routine evaluations of elderly patients with AF.
Consider comprehensive management strategies addressing both AF and inflammatory markers.
