Case Study: Two Instances of Idiopathic Plasmacytic Lymphadenopathy, a Subtype of Idiopathic Multicentric Castleman Disease, Accompanied by Xanthelasma Palpebrum from a Canadian Institution - Scorecard - MDSpire

Case Study: Two Instances of Idiopathic Plasmacytic Lymphadenopathy, a Subtype of Idiopathic Multicentric Castleman Disease, Accompanied by Xanthelasma Palpebrum from a Canadian Institution

  • By

  • Andrew A. Y. Chen

  • Vivian T. Yin

  • Paula Blanco

  • Mark Trinder

  • Richard I. Crawford

  • Ryan Henrie

  • Stephen Parkin

  • Nasreen Khalil

  • Mollie Carruthers

  • Lu Zhang

  • Luke Y. C. Chen

  • February 23, 2026

  • 0 min

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Clinical Scorecard: Case Study: Two Instances of Idiopathic Plasmacytic Lymphadenopathy, a Subtype of Idiopathic Multicentric Castleman Disease, Accompanied by Xanthelasma Palpebrum from a Canadian Institution

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationAsian women in their 5th decade with chronic lymphadenopathy and inflammation.
Care Setting

Key Highlights

  • Normolipemic xanthelasma palpebrum is a novel finding specifically in iMCD-IPL.

Guideline-Based Recommendations

Diagnosis

  • Diagnosis requires clinicopathological correlation and expertise in Castleman disease, emphasizing the need for thorough histological evaluation.

Management

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Siltuximab may provide partial clinical and biochemical response, but responses can vary significantly among patients.

        Clinical Best Practices

        • Consider a multidisciplinary approach involving hematologists and pathologists for accurate diagnosis and management.

        References

        Original Source(s)

        Case Study: Two Instances of Idiopathic Plasmacytic Lymphadenopathy, a Subtype of Idiopathic Multicentric Castleman Disease, Accompanied by Xanthelasma Palpebrum from a Canadian Institution

        • by Andrew A. Y. Chen, Vivian T. Yin, Paula Blanco, Mark Trinder, Richard I. Crawford, Ryan Henrie, Stephen Parkin, Nasreen Khalil, Mollie Carruthers, Lu Zhang, Luke Y. C. Chen

        • February 23, 2026

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