Human seminal plasma suppresses neutrophil antimicrobial functions and promotes bacterial survival - Scorecard - MDSpire

Human seminal plasma suppresses neutrophil antimicrobial functions and promotes bacterial survival

  • By

  • Gabriel Mayoral-Andrade

  • Gabriela Vásquez-Martínez

  • Israel Cotzomi-Ortega

  • Gamaliel Sánchez-Orellana

  • Jeimy M. Lopez-Torres

  • Diana Zepeda-Orozco

  • Laura Pérez-Campos Mayoral

  • María Teresa Hernández-Huerta

  • Abraham Salvador Majluf-Cruz

  • María del Socorro Pina-Canseco

  • Margarito Martínez-Cruz

  • Gabriel Mayoral-Canseco

  • Carlos Alejandro Vásquez-Martínez

  • Víctor Cruz Hernández

  • Luz María Moreno Pombo

  • Adriana Carriedo Blanco

  • Eduardo Pérez-Campos Mayoral

  • Héctor Martínez-Ruiz

  • Eduardo Pérez-Campos

  • Juan de Dios Ruiz-Rosado

  • July 14, 2026

Share

Clinical Scorecard: Human Seminal Plasma Inhibits Neutrophil Antimicrobial Activity and Enhances Bacterial Persistence

At a Glance

CategoryDetail
ConditionHuman Seminal Plasma Effects on Neutrophils
Key MechanismsInhibition of ROS production, NET formation, and phagocytosis
Target PopulationHealthy individuals and animal models
Care SettingImmunomodulatory research in reproductive health

Key Highlights

  • HSP significantly suppresses neutrophil ROS production and NET formation.
  • Impairment of neutrophil phagocytic capacity and bacterial killing observed.
  • HSP-mediated inhibition of NETosis is PAD4-dependent but NOX2-independent.
  • Prostaglandin E2 signaling is implicated in reduced neutrophil oxidative burst.
  • HSP plays a role in maintaining immune homeostasis in the reproductive tract.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

        Risks

          Patient & Prescribing Data

          Healthy individuals providing seminal plasma

          Acetylsalicylic acid pretreatment reduces prostaglandin E2 levels in HSP.

          Clinical Best Practices

          • Consider the immunomodulatory effects of HSP in reproductive health.
          • Evaluate the role of neutrophil effector functions in pathogen clearance.

          Related Resources & Content

            Original Source(s)

            Human seminal plasma suppresses neutrophil antimicrobial functions and promotes bacterial survival

            • by Gabriel Mayoral-Andrade, Gabriela Vásquez-Martínez, Israel Cotzomi-Ortega, Gamaliel Sánchez-Orellana, Jeimy M. Lopez-Torres, Diana Zepeda-Orozco, Laura Pérez-Campos Mayoral, María Teresa Hernández-Huerta, Abraham Salvador Majluf-Cruz, María del Socorro Pina-Canseco, Margarito Martínez-Cruz, Gabriel Mayoral-Canseco, Carlos Alejandro Vásquez-Martínez, Víctor Cruz Hernández, Luz María Moreno Pombo, Adriana Carriedo Blanco, Eduardo Pérez-Campos Mayoral, Héctor Martínez-Ruiz, Eduardo Pérez-Campos, Juan de Dios Ruiz-Rosado

            • July 14, 2026

            Related Content

            Measles-Containing Vaccine Use for Children Aged 12 to 47 Months, 2015 to 2025

            Global research landscape and trends of single-cell sequencing in sexually transmitted infections: a comprehensive bibliometric analysis from 2015 to 2025

            Case Report: Hemophagocytic lymphohistiocytosis secondary to Escherichia coli infiltration of bone marrow in a patient with seronegative rheumatoid arthritis treated with low-dose methotrexate