Small-cell neuroendocrine carcinoma of the descending colon in a young adult: a case report
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By
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Rong-Chao Zhou
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Gang Zhou
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Zhe Liang
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May 25, 2026
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Clinical Scorecard: Case Study of Small-Cell Neuroendocrine Carcinoma in the Descending Colon of a Young Adult
At a Glance
| Category | Detail |
|---|
| Condition | Small-Cell Neuroendocrine Carcinoma (SCNEC) of the Descending Colon |
| Key Mechanisms | Arises from neuroendocrine cells with malignant potential; characterized by atypical imaging features. |
| Target Population | Young adults, specifically noted in a 25-year-old male. |
| Care Setting | Hospital emergency department and oncology care. |
Key Highlights
- SCNEC is rare, particularly in young adults and in the descending colon.
- Initial imaging findings can mimic inflammatory disease.
- Histopathology and immunohistochemistry are essential for definitive diagnosis.
- The patient experienced significant weight loss and intestinal obstruction.
- Elevated tumor markers were noted upon readmission.
Guideline-Based Recommendations
Diagnosis
- Consider colonic neuroendocrine neoplasms in differential diagnosis for young patients with abdominal symptoms.
- Early endoscopic biopsy is recommended for definitive diagnosis.
Management
- Etoposide plus cisplatin chemotherapy was administered, though response was poor.
Monitoring & Follow-up
- Regular monitoring of tumor markers is advised to assess disease progression.
Risks
- Delayed diagnosis due to patient refusal for further evaluation can lead to disease progression.
Patient & Prescribing Data
Young adults with rare cases of SCNEC.
Combination chemotherapy may be necessary, but responses can vary.
Clinical Best Practices
- Include colonic NENs in differential diagnosis for abdominal pain in young patients.
- Utilize imaging and tumor markers to guide diagnosis and treatment.
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