Skin barrier dysfunction and correlation with the onset and progression of psoriasis
By
Ying Wang
Yanyang Liang
Jianxiao Xing
Junqin Li
Kaiming Zhang
June 30, 2026
Clinical Scorecard: Dysfunction of the Skin Barrier and Its Relationship with the Development and Advancement of Psoriasis
At a Glance
Category Detail
Condition Psoriasis Key Mechanisms Skin barrier dysfunction, immune dysregulation, genetic predisposition, environmental triggers. Target Population Individuals with psoriasis, particularly those with lesions in areas of poor skin barrier function. Care Setting Clinical dermatology and research settings.
Key Highlights
Skin barrier dysfunction is an early and pivotal driver of psoriasis. Aberrant keratinocyte hyperproliferation and tight junction disruption are key mechanisms. Restoration of skin barrier function is clinically significant in psoriasis management. Psoriasis has a global prevalence of 0.1% to 3% and imposes a heavy burden on patients. Research gaps exist in the molecular mechanisms and clinical applications of skin barrier repair. Guideline-Based Recommendations
Diagnosis
Assess skin barrier function as part of the diagnostic process for psoriasis. Management
Consider skin barrier restoration strategies in the management of psoriasis. Monitoring & Follow-up
Evaluate barrier-related indicators in relation to disease severity and treatment response. Risks
Patients may experience high recurrence rates and treatment resistance, particularly in areas with poor skin barrier function. Patient & Prescribing Data
Patients diagnosed with psoriasis, especially those with compromised skin barrier function.
Current therapies include immunosuppressants, biological agents, and phototherapy, but treatment resistance is common.
Clinical Best Practices
Integrate assessment of skin barrier function into routine psoriasis evaluations. Focus on targeted therapeutic strategies that address skin barrier dysfunction. Stay updated on emerging research regarding the correlation between skin barrier and psoriasis. Related Resources & Content
