Maternal TSH and FT4 changes during pregnancy as risk factors for preeclampsia in euthyroid women
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By
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Jianxia Lin
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Yili Zhang
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Yu Meng
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Yan Su
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Mengfan Song
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May 26, 2026
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Clinical Scorecard: Changes in Maternal TSH and FT4 Levels Throughout Pregnancy as Potential Risk Indicators for Preeclampsia in Euthyroid Women
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Changes in TSH and FT4 levels during pregnancy as observed in the study. |
| Target Population | |
| Care Setting | |
Key Highlights
- TSH changes show a J-shaped nonlinear association with preeclampsia risk.
- FT4 changes are linearly and negatively associated with preeclampsia risk.
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
- Significant increases in TSH combined with decreases in FT4 are associated with higher risk of preeclampsia.
Patient & Prescribing Data
Pregnant women with normal thyroid function
Monitoring thyroid hormone levels may help identify risk for preeclampsia.
Clinical Best Practices
- Utilize trimester-specific reference ranges for TSH and FT4 in pregnant women.
- Conduct systematic prenatal examinations to monitor thyroid function.
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