Overcoming immunotherapy resistance in triple-negative breast cancer: a critical review of mast cell plasticity, metabolic reprogramming, and organoid models - Scorecard - MDSpire
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Overcoming immunotherapy resistance in triple-negative breast cancer: a critical review of mast cell plasticity, metabolic reprogramming, and organoid models
Clinical Scorecard: Addressing Resistance to Immunotherapy in Triple-Negative Breast Cancer: An In-Depth Analysis of Mast Cell Adaptability, Metabolic Changes, and Organoid Systems
At a Glance
Category
Detail
Condition
Key Mechanisms
Target Population
Patients with advanced TNBC.
Care Setting
Key Highlights
Mast cells exhibit high phenotypic diversity, including antigen-presenting capabilities.
Metabolic dysregulation in TNBC skews mast cells toward immunosuppressive phenotypes.
Patient-derived organoid models facilitate the study of tumor-immune interactions.
Guideline-Based Recommendations
Diagnosis
Management
Consider modulation of antigen-presenting mast cells.
