Vitamin D-related genetic variants as predictive biomarkers for breast cancer in Jordanian women
By
Laith N. Al-Eitan
Maryam K. Alasmar
Mohammed S. Alorjani
Lina M. Sarhan
Sakher S. Sammour
Farah N. Aladwan
Hadil A. Al Refai
Sara S. Hasanat
Mira S. Quran
Mansour A. Alghamdi
May 28, 2026
Clinical Scorecard: Genetic Variants Associated with Vitamin D as Predictive Markers for Breast Cancer Risk in Women from Jordan
At a Glance
Category Detail
Condition Breast Cancer Key Mechanisms Genetic polymorphisms in CYP2R1 and CYP27B1 affecting vitamin D metabolism and signaling. Target Population Jordanian females Care Setting Chemotherapy Clinics of King Abdullah University Hospital and King Hussein Medical Center
Key Highlights
Significant associations found for CYP2R1 rs12794714 and CYP27B1 rs10877012 genotypes. GG genotype of CYP2R1 and TG genotype of CYP27B1 linked to reduced breast cancer risk. No significant associations for CYP2R1 rs10741657, CYP24A1 rs2248359, or DBP variants. Guideline-Based Recommendations
Diagnosis
Assess genetic polymorphisms in CYP2R1 and CYP27B1 for breast cancer susceptibility. Management
Consider vitamin D levels and genetic factors in breast cancer risk assessment. Monitoring & Follow-up
Monitor vitamin D levels and associated genetic variants in at-risk populations. Risks
Increased breast cancer risk may be associated with certain genetic polymorphisms. Patient & Prescribing Data
Women from Jordan with and without breast cancer.
Further studies recommended to validate the protective role of specific genotypes.
Clinical Best Practices
Incorporate genetic testing for vitamin D metabolism-related genes in breast cancer risk evaluations. Educate patients on the role of vitamin D in cancer prevention. Related Resources & Content
