Development Process of a Clinical Decision Support System for Empiric Antibiotic Therapies in Patients With Sepsis: Case Study
By
Sophie Schmiegel
Hannah Marchi
Philipp Hege
Svenja Elkenkamp
Juliane Duevel
Christoph Düsing
Wolfgang Greiner
Sean Selim Scholz
Dominic Witzke
Johannes J Tebbe
Michael Wehmeier
Olaf Kaup
Rainer Borgstedt
Sebastian Rehberg
Philipp Cimiano
Christiane Fuchs
May 13, 2026
Clinical Scorecard: Creation of a Clinical Decision Support Tool for Empirical Antibiotic Treatment in Sepsis Patients: A Case Analysis
At a Glance
Category Detail
Condition Sepsis Key Mechanisms Dysregulated host response to infection leading to organ dysfunction. Target Population Patients diagnosed with sepsis or septic shock. Care Setting Hospital emergency departments and intensive care units.
Key Highlights
Sepsis is a leading cause of global morbidity and mortality. Empiric broad-spectrum antibiotics are critical for initial treatment. Timely administration of antibiotics significantly improves survival rates. Antibiotic resistance is a major concern in sepsis management. AI-based clinical decision support systems can enhance treatment decisions. Guideline-Based Recommendations
Diagnosis
Utilize the SOFA score to assess organ dysfunction. Measure lactate levels and perform antibiotic susceptibility testing. Management
Administer broad-spectrum antibiotics immediately upon diagnosis. Initiate fluid resuscitation and vasopressor therapy as needed. Monitoring & Follow-up
Reassess lactate levels after initial treatment. Monitor for signs of organ dysfunction and antibiotic effectiveness. Risks
Potential for antibiotic resistance due to inappropriate prescriptions. Side effects from broad-spectrum antibiotics, including gastrointestinal issues. Patient & Prescribing Data
Patients with suspected or confirmed sepsis.
Early and effective antibiotic therapy is crucial; consider local resistance patterns.
Clinical Best Practices
Implement antibiotic stewardship programs to minimize resistance. Utilize AI tools for personalized antibiotic therapy recommendations. Ensure rapid diagnosis and treatment initiation to improve outcomes. Related Resources & Content
