External validation of a machine learning-based web application for personalized testing of objective functioning using the five-repetition sit-to-stand test - Scorecard - MDSpire
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Validation of a Machine Learning-Driven Web Tool for Customized Assessment of Objective Functioning via the Five-Repetition Sit-to-Stand Test

  • By

  • Kenneth Arockia

  • Massimo Bottini

  • Anita M. Klukowska

  • Victor Gabriel El-Hajj

  • Maria Gharios

  • Ali Buwaider

  • Carlo Serra

  • Luca Regli

  • Marc L. Schröder

  • Victor E. Staartjes

  • August 18, 2026

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Clinical Scorecard: Validation of a Machine Learning-Driven Web Tool for Customized Assessment of Objective Functioning via the Five-Repetition Sit-to-Stand Test

At a Glance

CategoryDetail
ConditionObjective Functional Impairment (OFI)
Key MechanismsMachine learning model incorporating demographic variables to personalize assessment thresholds for the 5R-STS test.
Target PopulationHealthy individuals without functional impairment.
Care SettingNeurosurgical practice and research.

Key Highlights

  • 5R-STS test time over 10.4 seconds indicates objective functional impairment.
  • Machine learning model improves classification accuracy by personalizing ULN based on demographics.
  • External validation conducted on a diverse cohort across multiple countries.

Guideline-Based Recommendations

Diagnosis

  • Use the 5R-STS test to assess functional impairment.

Management

  • Employ personalized machine learning models for accurate assessment.

Monitoring & Follow-up

  • Regularly validate models across different demographics and settings.

Risks

  • Generalized assessment may misclassify patients due to individual factors.

Patient & Prescribing Data

Healthy volunteers from various countries.

Utilization of a web application for automated assessment of 5R-STS test times.

Clinical Best Practices

  • Incorporate demographic data into functional assessments.
  • Ensure standardized testing protocols for the 5R-STS test.

Related Resources & Content

Original Source(s)

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