Benefits of virtual reality rehabilitation on neurodegenerative diseases: a systematic review - Scorecard - MDSpire

Benefits of virtual reality rehabilitation on neurodegenerative diseases: a systematic review

  • By

  • Tiantaixi Tu

  • Ye Yang

  • Tongtong Zheng

  • Hangqi Lin

  • Weimin Wang

  • Linglin Fu

  • Songhe Jiang

  • Rui Wang

  • December 9, 2025

  • 0 min

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Clinical Scorecard: Advantages of Virtual Reality Therapy for Neurodegenerative Disorders: A Comprehensive Review

At a Glance

CategoryDetail
ConditionNeurodegenerative diseases including Parkinson’s disease, cognitive impairment, and multiple sclerosis
Key MechanismsVirtual reality (VR) rehabilitation enhances motor and cognitive function through immersive, semi-immersive, and non-immersive environments that promote neuroplasticity, motivation, and engagement
Target PopulationPatients with neurodegenerative diseases experiencing motor, cognitive, and emotional impairments
Care SettingClinical rehabilitation settings and home-based therapy using VR systems

Key Highlights

  • VR rehabilitation improves motor function, cognitive function, and quality of life in neurodegenerative disease patients.
  • Different VR modalities (immersive, semi-immersive, non-immersive) offer tailored therapeutic benefits based on patient needs and treatment goals.
  • VR therapy enhances patient motivation, adherence, and emotional well-being compared to traditional rehabilitation.

Guideline-Based Recommendations

Diagnosis

  • Identify neurodegenerative disease subtype and assess motor and cognitive impairments to tailor VR interventions.

Management

  • Incorporate VR rehabilitation as a complementary therapy to traditional pharmacotherapy and rehabilitation.
  • Select VR modality (immersive, semi-immersive, non-immersive) based on patient capability, clinical objectives, and resource availability.
  • Customize task difficulty within VR to match patient’s evolving functional status and promote neuroplasticity.

Monitoring & Follow-up

  • Regularly evaluate motor and cognitive function improvements and patient engagement during VR therapy.
  • Monitor adherence and emotional well-being to optimize therapy protocols.

Risks

  • Consider potential technology disparities and patient heterogeneity when implementing VR therapy.
  • Be aware of possible limitations related to cost, accessibility, and patient compliance.

Patient & Prescribing Data

Patients diagnosed with Parkinson’s disease, cognitive impairment, multiple sclerosis, and related neurodegenerative disorders

VR interventions have demonstrated efficacy in improving strength, balance, walking ability, upper limb function, cognitive and daily functioning, and emotional well-being.

Clinical Best Practices

  • Use immersive VR with head-mounted displays for high presence and emotional regulation when feasible.
  • Employ semi-immersive VR for greater accessibility and adherence while maintaining moderate immersion.
  • Utilize non-immersive VR for cost-effective home rehabilitation solutions.
  • Incorporate gamified and engaging VR tasks to enhance motivation and compliance.
  • Standardize VR rehabilitation protocols and further investigate underlying neurobiological mechanisms.

References

Original Source(s)

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