Spatially microdissected profiling of tonsillar germinal centers reveals a KLRG1-enriched immune signature in IgA nephropathy - Scorecard - MDSpire

Spatially microdissected profiling of tonsillar germinal centers reveals a KLRG1-enriched immune signature in IgA nephropathy

  • By

  • Mayuko Kawabe

  • Izumi Yamamoto

  • Yutaro Ohki

  • Ayaka Hayashi

  • Go Kanzaki

  • Kei Matsumoto

  • Hiroyuki Ueda

  • Keita Hirano

  • Nobuo Tsuboi

  • Takashi Yokoo

  • May 22, 2026

  • 0 min

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Clinical Scorecard: Microdissection of Tonsillar Germinal Centers Uncovers a KLRG1-Dominant Immune Profile in IgA Nephropathy

At a Glance

CategoryDetail
Condition
Key MechanismsKLRG1-enriched immune signature in tonsillar germinal centers (source needed)
Target Population
Care SettingElective tonsillectomy at Jikei University School of Medicine, Tokyo, Japan (source needed)

Key Highlights

  • KLRG1 expression upregulated in IgAN tonsillar germinal centers (fold change 3.2, p < 0.001)
  • Differential expression of immune-related genes observed between IgAN and control groups (source needed)
  • Immunohistochemistry confirmed GC-localized KLRG1 expression in IgAN patients (source needed)

Guideline-Based Recommendations

Diagnosis

    Management

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    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Five patients with biopsy-proven IgAN and five matched controls with habitual tonsillitis

        Clinical benefit of tonsillectomy varies by geographic region

        Clinical Best Practices

        • Utilize laser microdissection for precise immune profiling of tonsillar tissue (source needed)

        Related Resources & Content

        Original Source(s)

        Spatially microdissected profiling of tonsillar germinal centers reveals a KLRG1-enriched immune signature in IgA nephropathy

        • by Mayuko Kawabe, Izumi Yamamoto, Yutaro Ohki, Ayaka Hayashi, Go Kanzaki, Kei Matsumoto, Hiroyuki Ueda, Keita Hirano, Nobuo Tsuboi, Takashi Yokoo

        • May 22, 2026

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