Deoxycholic acid promotes anxiety- and depression-like behaviors in mice via modulation of the gut microbial metabolite indole-3-propionic acid - Scorecard - MDSpire
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Deoxycholic acid promotes anxiety- and depression-like behaviors in mice via modulation of the gut microbial metabolite indole-3-propionic acid
Clinical Scorecard: Deoxycholic Acid Influences Anxiety and Depression Behaviors in Mice Through Alteration of Gut Microbial Metabolite Indole-3-Propionic Acid
At a Glance
Category
Detail
Condition
Key Mechanisms
Target Population
Mice models subjected to high-fat diet
Care Setting
Key Highlights
DCA induces anxiety- and depression-like behaviors in mice.
Reduction of Clostridium_sensu_stricto_1 and IPA levels linked to DCA.
IPA supplementation ameliorates DCA-induced emotional and behavioral abnormalities.
Fecal microbiota transplantation (FMT) mimics DCA model phenotypes.
Targeting bile acid metabolism may offer intervention strategies.
Findings suggest potential implications for human health.
Guideline-Based Recommendations
Diagnosis
Behavioral phenotyping and transcriptome sequencing to assess anxiety and depression-like behaviors, using specific protocols.
Management
Restoration of IPA levels and targeting abnormal bile acid metabolism.
Monitoring & Follow-up
Assessment of gut microbiota composition and intestinal barrier function.
Risks
Potential for intestinal barrier damage and neuroinflammatory responses due to elevated DCA.
Patient & Prescribing Data
DCA elevation linked to emotional disorders; IPA supplementation shows promise in reversing effects, though based on animal models.
Clinical Best Practices
Monitor gut microbiota and metabolites in patients with dietary-induced emotional disorders, focusing on specific species affected by DCA.
Consider bile acid binders as a potential therapeutic approach.
