Paired dosimetric comparison of VMAT-based total body and total marrow irradiation in adult leukemia patients: enhanced organ sparing with consistent plan complexity - Scorecard - MDSpire

Paired dosimetric comparison of VMAT-based total body and total marrow irradiation in adult leukemia patients: enhanced organ sparing with consistent plan complexity

  • By

  • Sevim Sahin

  • Abdullah Yesil

  • June 2, 2026

  • 0 min

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Clinical Scorecard: Comparative Dosimetric Analysis of VMAT-Driven Total Body and Total Marrow Irradiation in Adult Leukemia Patients: Improved Organ Protection with Consistent Planning Complexity

At a Glance

CategoryDetail
Condition
Key MechanismsTotal body irradiation (TBI) and total marrow irradiation (TMI) for conditioning prior to hematopoietic stem cell transplantation. [Citation needed]
Target Population
Care Setting

Key Highlights

  • TMI significantly reduced organ-at-risk doses compared to TBI (p < 0.001).
  • Mean doses to the heart, kidneys, and liver were reduced by approximately 5–6 Gy.
  • TMI showed improved dose homogeneity and lower planning complexity metrics.

Guideline-Based Recommendations

Diagnosis

    Management

    • Utilization of VMAT-based TBI or TMI in conditioning regimens for HSCT. [Citation needed]

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        30 adult patients (8 females, 22 males) diagnosed with AML or ALL.

        VMAT-based TMI offers a targeted approach to reduce radiation exposure to normal tissues.

        Clinical Best Practices

          Related Resources & Content

          Original Source(s)

          Paired dosimetric comparison of VMAT-based total body and total marrow irradiation in adult leukemia patients: enhanced organ sparing with consistent plan complexity

          • by Sevim Sahin, Abdullah Yesil

          • June 2, 2026

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