Clinical efficacy and cortical network modulation of a multimodal sensory feedback upper-limb rehabilitation robot for post-stroke upper-limb recovery: a randomized controlled trial - Scorecard - MDSpire
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Effectiveness and Cortical Network Alterations of a Multimodal Sensory Feedback Robot for Upper-Limb Rehabilitation in Post-Stroke Patients: A Randomized Controlled Study

  • By

  • Li-Hui Zhao

  • Jun-Peng Zhang

  • Jia-Jia Wu

  • Yu Cao

  • Zhan-Yue Lu

  • Xu-Yun Hua

  • Xia Bi

  • Jian-Guang Xu

  • September 4, 2026

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Clinical Scorecard: Effectiveness and Cortical Network Alterations of a Multimodal Sensory Feedback Robot for Upper-Limb Rehabilitation in Post-Stroke Patients: A Randomized Controlled Study

At a Glance

CategoryDetail
ConditionPost-stroke upper-limb rehabilitation
Key MechanismsMultimodal sensory feedback and robot-assisted training enhance patient engagement and sensorimotor integration.
Target PopulationIndividuals aged 40-75 years, right-handed, 2 weeks to 1 year post-stroke.
Care SettingDepartment of Rehabilitation Medicine at Zhoupu Hospital, Pudong New Area, Shanghai.

Key Highlights

  • Multimodal sensory-feedback robot-assisted training improved Fugl-Meyer Assessment scores significantly compared to conventional rehabilitation.
  • Functional near-infrared spectroscopy (fNIRS) indicated increased fronto-motor connectivity in the experimental group post-intervention.
  • No significant baseline differences in cortical measures between groups; significant changes observed post-intervention.

Guideline-Based Recommendations

Diagnosis

  • Stroke diagnosed using 2019 Chinese key diagnostic criteria and verified through CT or MRI.

Management

  • Supplement conventional rehabilitation with multimodal sensory-feedback robot-assisted training.

Monitoring & Follow-up

  • Utilize fNIRS to assess cortical activation and connectivity during rehabilitation.

Risks

  • Exclusion criteria include clinical worsening, psychiatric illness, and orthopedic disorders affecting limb movement.

Patient & Prescribing Data

38 individuals with stroke, aged 40-75 years.

Robot-assisted training provides scalable, intensive rehabilitation opportunities.

Clinical Best Practices

  • Incorporate multimodal sensory feedback in rehabilitation protocols.
  • Ensure patient engagement through interactive and adaptive training methods.

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