Obesity and the Initial Diagnosis of Mental Disorders: A Cohort Analysis of 10 Million Adults in the UK - Scorecard - MDSpire
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Obesity and the Initial Diagnosis of Mental Disorders: A Cohort Analysis of 10 Million Adults in the UK

  • By

  • Xue Dong

  • Paul Aveyard

  • Xiaochen Yang

  • Mika Kivimaki

  • Shanquan Chen

  • Joseph Firth

  • Cynthia Wright Drakesmith

  • Min Gao

  • November 29, 2025

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Clinical Scorecard: Obesity and the Initial Diagnosis of Mental Disorders: A Cohort Analysis of 10 Million Adults in the UK

At a Glance

CategoryDetail
ConditionMental Illness
Key MechanismsAssociation between BMI and first-onset mental illness diagnosis.
Target PopulationAdults aged 18 and older in the UK.
Care SettingPrimary care settings using electronic health records.

Key Highlights

  • 20%-60% of individuals with obesity experience a mental illness.
  • Obesity may increase mental illness risk through metabolic dysfunction.
  • Underweight individuals are at increased risk of depression.
  • Sex, age, and ethnicity may modify the association between BMI and mental illnesses.
  • Large-scale studies are needed to explore demographic patterns and associations.

Guideline-Based Recommendations

Diagnosis

  • Use BMI for diagnosing clinical obesity.
  • Consider WHtR for assessing central obesity.

Management

  • Monitor mental health in individuals with obesity and underweight.

Monitoring & Follow-up

  • Regularly assess BMI and WHtR in primary care.

Risks

  • Increased risk of cardiometabolic diseases and mental illness.

Patient & Prescribing Data

Adults with recorded BMI assessments in the UK.

Psychotropic medications may indicate mental illness diagnosis.

Clinical Best Practices

  • Incorporate BMI and WHtR assessments in mental health evaluations.
  • Address weight-related stigma in mental health care.

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