Roswell Park Researchers to Discuss Recent Discoveries and Critical Issues in Oncology at AACR 2025
Researchers from Roswell Park Comprehensive Cancer Center will report their latest findings to colleagues from around the world at the 2025 annual meeting of the American Association for Cancer Research (AACR) in Chicago, Illinois, April 25-30.
Clinical Scorecard: Roswell Park Researchers to Discuss Recent Discoveries and Critical Issues in Oncology at AACR 2025
At a Glance
Category Detail
Condition Various cancers including non-small cell lung cancer, breast cancer, multiple myeloma, and colorectal cancer Key Mechanisms A2a receptor antagonism, synergistic effects of tamoxifen and doxorubicin, CAR T cell responses, and DNA damage response vulnerabilities Target Population Patients with advanced cancers and Indigenous communities Care Setting Oncology research and clinical trials
Key Highlights
Phase 1 trial results for an A2a receptor antagonist in advanced non-small cell lung cancer Synergistic effects of tamoxifen and doxorubicin in triple-negative breast cancer Innovative immunotherapy strategies for p53 mutant metastatic breast cancer Research on sex disparities in bladder cancer Integration of serum and tumor metabolomics in early onset colorectal cancer Guideline-Based Recommendations
Diagnosis
Utilize clinical trials to assess new therapeutic strategies Incorporate patient navigation for Indigenous populations Management
Consider combination therapies for enhanced efficacy in cancer treatment Engage in partnerships with Indigenous nations to tailor cancer care Monitoring & Follow-up
Track patient responses to novel therapies in clinical trials Monitor metabolic profiles in cancer patients for personalized treatment Risks
Evaluate potential side effects of combination therapies Address disparities in cancer care for Indigenous populations Patient & Prescribing Data
Patients with advanced cancers, including Indigenous communities
Emerging therapies focus on combination strategies and addressing unique community needs
Clinical Best Practices
Foster collaborations between cancer centers and Indigenous nations Prioritize patient education and navigation services Implement research findings into clinical practice for improved patient outcomes References
