The prognostic value of the CALLY index in sepsis: a systematic review and meta-analysis
-
By
-
Chuangying Xie
-
Peng Sun
-
Min Zhang
-
Hong Fan
-
Zhenzhen Li
-
Xiang Tong
-
May 8, 2026
-
Clinical Scorecard: Evaluating the Prognostic Significance of the CALLY Index in Sepsis: A Comprehensive Meta-Analysis
At a Glance
| Category | Detail |
|---|
| Condition | Sepsis |
| Key Mechanisms | C-reactive protein, albumin, lymphocyte count |
| Target Population | Patients with sepsis |
| Care Setting | Clinical management of sepsis |
Key Highlights
- CALLY index shows variable prognostic value in sepsis across different ethnic cohorts.
- Higher CALLY index correlated with survival in Chinese cohorts but with mortality in Turkish cohorts.
- Moderate diagnostic accuracy for predicting mortality: sensitivity 0.59, specificity 0.77.
- Significant heterogeneity observed across pooled analyses.
- Potential for CALLY index as a low-cost biomarker in sepsis management.
Guideline-Based Recommendations
Diagnosis
- Utilize the CALLY index as a composite biomarker in sepsis evaluation.
Management
- Consider the CALLY index in conjunction with other biomarkers for prognostic assessment.
Monitoring & Follow-up
- Regularly assess CALLY index levels to evaluate patient prognosis.
Risks
- Be aware of variable prognostic implications of the CALLY index across different populations.
Patient & Prescribing Data
Patients diagnosed with sepsis
CALLY index may assist in identifying patients at higher risk of mortality.
Clinical Best Practices
- Incorporate CALLY index into routine sepsis assessments.
- Validate findings in larger, multinational studies.
Related Resources & Content
