Allergenicity assessment of novel foods - lessons from immune endotyping of food-allergic patients

Category	Detail
Condition
Key Mechanisms
Target Population	Individuals with food allergies, particularly children aged 0-18.
Care Setting

Food allergy affects up to 10% of the global population, with increasing prevalence among children. [Source needed]
Current guidelines for novel foods (NF) focus on potential IgE cross-reactivity but lack direction for unknown allergenic potential.
Immune endotyping can differentiate between food allergy, asymptomatic IgE sensitization, and healthy states.
Functional assays using immune cells can provide insights into the severity and reactivity of food allergies.
Regulatory frameworks for NF require safety assessments before market introduction.

Risk assessment of novel foods through a weight-of-evidence approach. [Source needed]

Patients with food allergies exhibiting diverse clinical reactivity profiles.

Endotyping approaches can help tailor management strategies based on individual immune responses.

Incorporate immune endotyping in the assessment of food allergies. [Source needed]
Utilize multiplex platforms for measuring molecular spreading of IgE responses. [Source needed]
Consider functional IgE-cross-linking tests to evaluate patient reactivity. [Source needed]

Clinical Scorecard: Evaluation of Allergenicity in Novel Foods: Insights from Immune Endotyping in Patients with Food Allergies