Connectome-based mapping of gray matter abnormalities in hepatic encephalopathy
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By
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Li Chen
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Lei Xia
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Yaling Chen
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Chengkun Hong
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Minghui Mao
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Xiaoyang Wang
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Lili Zhou
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July 10, 2026
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Clinical Scorecard: Mapping Gray Matter Abnormalities in Hepatic Encephalopathy Using Connectome Analysis
At a Glance
| Category | Detail |
|---|
| Condition | Hepatic Encephalopathy |
| Key Mechanisms | Gray matter abnormalities linked to structural and functional connectivity |
| Target Population | Patients with hepatic encephalopathy and healthy controls |
| Care Setting | Neuroimaging and connectome analysis |
Key Highlights
- Widespread gray matter abnormalities observed in prefrontal, motor, temporal, and limbic cortices.
- Structural neighborhood abnormalities positively correlated with cortical changes.
- Functional-connectome epicenters concentrated in left inferior frontal gyrus and orbitofrontal cortex.
- Individual analyses revealed heterogeneous epicenter patterns with prefrontal regions implicated.
- Study utilized high-resolution T1-weighted MRI and normative connectomes.
Guideline-Based Recommendations
Diagnosis
- Patients classified as HE based on documented episodes or evidence of HE at enrollment.
Management
- Focus on understanding neurobiological basis and network architecture of HE.
Monitoring & Follow-up
- Assess neuropsychological performance and imaging markers longitudinally.
Risks
- Higher mortality risk and reduced quality of life associated with HE.
Patient & Prescribing Data
45 patients with hepatic encephalopathy and 45 healthy controls.
No specific treatment insights provided; focus on neuroimaging findings.
Clinical Best Practices
- Utilize connectome-based approaches for understanding HE-related abnormalities.
- Consider structural and functional connectivity in assessing HE.
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