The Transdiagnostic Oncology Program (TOP): A Comprehensive Lifestyle Intervention Aimed at Enhancing Quality of Life for Cancer Survivors - A Pilot Study with Pre- and Post-Intervention Analysis in Primary Care - Scorecard - MDSpire

The Transdiagnostic Oncology Program (TOP): A Comprehensive Lifestyle Intervention Aimed at Enhancing Quality of Life for Cancer Survivors - A Pilot Study with Pre- and Post-Intervention Analysis in Primary Care

  • By

  • Sanne H. Booij

  • Amy Pieper

  • Christianne D. Wester

  • Ute Bültmann

  • Elkana C. Waarsenburg

  • H. J. Rogier Hoenders

  • November 10, 2025

  • 0 min

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Clinical Scorecard: The Transdiagnostic Oncology Program (TOP): A Comprehensive Lifestyle Intervention Aimed at Enhancing Quality of Life for Cancer Survivors - A Pilot Study with Pre- and Post-Intervention Analysis in Primary Care

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationCancer survivors experiencing fatigue, anxiety, depression, and cognitive impairments, with varying recency of onset.
Care Setting

Key Highlights

  • TOP is a 12-month multidomain lifestyle intervention for cancer survivors, showing improvements in specific quality of life metrics.
  • Interdisciplinary approach addresses multiple transdiagnostic clinical problems.
  • Primary care-led programs are more cost-effective and widely applicable.
  • Previous pilot studies indicated feasibility and improvements in quality of life.
  • Secondary outcomes include happiness, fatigue, mental health, and work ability.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Evaluate quality of life and intermediate outcomes at baseline, mid-intervention, and post-intervention, using specific metrics such as EQ-5D or WHOQOL.

      Risks

        Patient & Prescribing Data

        Interventions should include exercise, dietary changes, and psychological support, such as cognitive behavioral therapy or mindfulness-based stress reduction.

        Clinical Best Practices

        • Utilize an interdisciplinary approach to address diverse needs of cancer survivors.
        • Incorporate mind-body interventions (e.g., yoga, meditation) and psycho-oncology strategies.
        • Encourage lifestyle changes to enhance self-management and reduce recurrence risk.

        References

        Original Source(s)

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