Gut microbiota-induced elevation of succinate exacerbates diabetic myocardial ischemia/reperfusion injury by promoting macrophage polarization
By
Yang Wu
Juan Dou
Min Liu
Song Peng
Wenyuan Li
June 10, 2026
Clinical Scorecard: Microbiota-Derived Succinate Elevation Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Models Through Macrophage Polarization
At a Glance
Category Detail
Condition Key Mechanisms Target Population Diabetic patients, particularly those with type 2 diabetes, at risk for myocardial ischemia/reperfusion injury. Care Setting
Key Highlights
Diabetes increases susceptibility to myocardial ischemia/reperfusion injury. Gut microbiota-derived succinate exacerbates myocardial injury through macrophage polarization. Antibiotic-mediated depletion of gut microbiota reverses succinate accumulation. SUCNR1 signaling pathway is critical in mediating the effects of succinate on macrophages. Targeting microbial succinate production may offer therapeutic strategies. Macrophage polarization plays a significant role in myocardial injury outcomes. Guideline-Based Recommendations
Diagnosis
Assess gut microbiota composition and succinate levels in diabetic patients using specific diagnostic criteria. Management
Consider interventions targeting succinate accumulation and macrophage polarization. Monitoring & Follow-up
Monitor succinate levels and macrophage polarization markers in diabetic patients. Risks
Increased myocardial injury and mortality in diabetic patients due to succinate accumulation. Patient & Prescribing Data
Exogenous succinate supplementation may worsen myocardial injury; caution is advised.
Clinical Best Practices
Evaluate the role of gut microbiota in diabetic patients with cardiovascular disease. Implement specific strategies to modulate macrophage polarization in myocardial injury. Related Resources & Content
