Clinical Scorecard: Strain Patterns Observed in Patients Diagnosed with Mitral Valve Prolapse
At a Glance
Category
Detail
Condition
Clinical topic addressed by the source article: Strain Patterns Observed in Patients Diagnosed with Mitral Valve Prolapse
Key Mechanisms
MVP-related basal structural and mechanical abnormalities, including systolic curling and mitral annular disjunction, are described as affecting myocardial mechanics. CMR feature tracking is used for strain analysis.
MVP affects approximately 2–3% of the population and typically has a favorable prognosis, although significant mitral regurgitation or ventricular arrhythmias can occur.
The study aimed to characterize global and regional longitudinal endocardial strain in the left ventricle, as well as strain in the right ventricle and left atrium.
CMR feature tracking uses standard CMR sequences and can be applied retrospectively to previously acquired scans.
Prior CMR feature-tracking studies reported inconsistent strain findings in MVP; the excerpt notes that regional CMR strain data remain scarce.
Strain values from CMR feature tracking and speckle-tracking echocardiography cannot be directly compared because the modalities assess strain using distinct technical principles.
Guideline-Based Recommendations
Diagnosis
In this study, MVP was defined as displacement of either the anterior or posterior leaflet by more than 2 mm above the valve level in the three-chamber view.
Management
Monitoring & Follow-up
Risks
The article states that significant mitral valve regurgitation or ventricular arrhythmias can develop in some patients with MVP.
The article describes FLNC mutations as associated with increased risk of arrhythmogenic complications.
Patient & Prescribing Data
Retrospective study of patients who underwent CMR at the institution from January 1, 2013, through December 31, 2022, with MVP visible on cine images; the earliest examination was evaluated when multiple examinations were available. Controls were individuals without apparent heart disease from five earlier prospective studies who underwent CMR at the institution. The supplied excerpt lists exclusions including age under 18 years, coronary heart disease, moderate or severe valvular disease, and myocardial wall thickness greater than 15 mm; the remaining exclusion criteria are not available in the excerpt.
The supplied excerpt reports no treatment or prescribing data; the study evaluates CMR-derived strain patterns.
Clinical Best Practices
The article states that MVP-related basal abnormalities, including systolic curling and mitral annular disjunction, affect myocardial mechanics.
The article states that strain values from CMR feature tracking and speckle-tracking echocardiography cannot be directly compared because the modalities use distinct technical principles.
The article describes CMR feature tracking as requiring standard CMR sequences and being applicable retrospectively to previously acquired scans.
by Jeffrey Ji-Peng Li, Shing Ching, Annette Aigner, Frank Edelmann, Stefanie Maria Werhahn, Rebecca Beyer, Jeanette Schulz-Menger, Jennifer Erley, Misael Estepa, Cyrill Meuwly, Ann-Sophie Eggers, Christian Stehning, Djawid Hashemi, Natalia Solowjowa, Christoph Klein, Ingo Hilgendorf, Sebastian Kelle, Patrick Doeblin
Review identifies recurring sex-based differences across specialties, including lower use of intensive and guideline-compliant treatment among female patients.
