CURE: a phase-based therapeutic framework for chronic inflammation
-
By
-
Nils Kurzen
-
Stefan Weißinger
-
Hjalmar Kurzen
-
June 15, 2026
-
Clinical Scorecard: CURE: A Therapeutic Approach for Managing Chronic Inflammation Based on Phased Interventions
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Cytokine redundancy, tissue-resident immune memory, self-reinforcing feedback loops contributing to chronic inflammation |
| Target Population | |
| Care Setting | |
Key Highlights
- CURE framework consists of CONTROL, UNLOAD and RESET, EQUILIBRATE phases, not implying curative eradication
- Focus on durable disease control and relapse prevention
- Therapeutic intensity aligned with immune system dynamics
- Integration of mechanistic and clinical evidence across multiple conditions
- Proactive, phase-specific immune stabilization
Guideline-Based Recommendations
Diagnosis
Management
- Implement phase-based therapeutic interventions according to the CURE framework, including specific examples
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Therapeutic exposure should suppress inflammatory feedback loops below critical thresholds, with specific strategies outlined
Clinical Best Practices
- Utilize structured, phase-based approaches for therapy
- Monitor for immunological tipping points to guide treatment adjustments
- Focus on long-term maintenance of immune equilibrium
- Emphasize individualized treatment plans based on patient response
Related Resources & Content
