Emerging insights into the role of BDH1 in the pathogenesis of human cancer
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By
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Penghui Wang
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Yunmeng Yan
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Zhengrong Liu
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Guoxun Feng
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Wei Yu
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June 3, 2026
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Clinical Scorecard: New Perspectives on the Involvement of BDH1 in the Development of Human Cancer
At a Glance
| Category | Detail |
|---|
| Condition | Cancer |
| Key Mechanisms | BDH1 catalyzes the reversible conversion of β-hydroxybutyrate (BHB) to acetoacetate (AcAc), influencing tumor energy metabolism and stress resistance. |
| Target Population | Patients with various malignancies |
| Care Setting | Oncology |
Key Highlights
- BDH1 plays a critical role in ketone body metabolism and energy homeostasis.
- Dysregulation of BDH1 is associated with aggressive tumor phenotypes and poor outcomes.
- BDH1 may serve as a prognostic biomarker and therapeutic target in precision oncology.
Guideline-Based Recommendations
Diagnosis
- Monitor BDH1 expression levels as a potential biomarker in cancer.
Management
- Consider targeting BDH1 in therapeutic strategies, including ketogenic diets and mitochondrial-targeted therapies.
Monitoring & Follow-up
- Assess metabolic adaptations in tumors related to BDH1 activity.
Risks
- Altered BDH1 expression may contribute to tumor microenvironment adaptation and immune evasion.
Patient & Prescribing Data
Individuals with cancer exhibiting altered BDH1 expression.
Targeting BDH1 may enhance therapeutic responses in certain malignancies.
Clinical Best Practices
- Evaluate BDH1's role in metabolic reprogramming in cancer patients.
- Incorporate metabolic profiling in cancer treatment planning.
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