Assessment of the aggregate index of systemic inflammation in dyslipidemia with dry eye disease: a retrospective case-control
By
Amani Y. Alhalwani
Asma Altasan
Nawaf Alasmari
Asma Almutiri
Mustafa Sunbul
Razan Khalifa
Jumanah Makhtoum
Shatha Jambi
June 11, 2026
Clinical Scorecard: Evaluation of Systemic Inflammation Index in Patients with Dyslipidemia and Dry Eye Disease: A Retrospective Case-Control Study
At a Glance
Category Detail
Condition Dyslipidemia and Dry Eye Disease Key Mechanisms Inflammation assessed via aggregate index of systemic inflammation (AISI) and inflammatory biomarkers like C-reactive protein (CRP). Target Population Patients diagnosed with dyslipidemia, specifically those with and without dry eye disease. Care Setting Outpatient clinic at King Abdulaziz Medical City, Jeddah, Saudi Arabia.
Key Highlights
DLP is prevalent in 43% of the Saudi population. Higher neutrophil and monocyte counts were observed in DLP-DED patients compared to DLP-only patients. AISI positively correlated with CRP and negatively correlated with HDL and total cholesterol. DED is characterized by discomfort, blurred vision, and tear-film instability. Inflammation may act as both a cause and effect in the relationship between DLP and DED. Guideline-Based Recommendations
Diagnosis
Diagnosis of DLP and DED based on clinical assessment. Management
Control lipid levels to prevent and treat DED. Monitoring & Follow-up
Monitor lipid profiles and inflammatory biomarkers in patients with DLP. Risks
Increased levels of triglycerides, LDL cholesterol, and total cholesterol are associated with a higher risk of DED. Patient & Prescribing Data
Patients with dyslipidemia, with a focus on those also diagnosed with dry eye disease.
Further evaluation of inflammatory biomarkers may improve understanding of DED pathogenesis.
Clinical Best Practices
Consider the aggregate index of systemic inflammation (AISI) as a biomarker for systemic inflammation in DLP. Evaluate the correlation between lipid profiles and dry eye disease progression. Related Resources & Content
