Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers - Scorecard - MDSpire

Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers

  • By

  • Jing Zhou

  • Qian Zhang

  • Chunmei Wang

  • Tingting Zhao

  • Tongtong Qiu

  • Guojie Xu

  • Cuiying Gu

  • Lihua Yu

  • Zhanyuan Yu

  • May 25, 2026

  • 0 min

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Clinical Scorecard: Dysregulation of Zinc Homeostasis in Older Adults with Acute Ischemic Stroke: A Comprehensive Analysis of Metallothionein, FADS1 Activity, Oxidative Stress, and DNA Damage Indicators

At a Glance

CategoryDetail
Condition
Key MechanismsZinc homeostasis dysregulation, oxidative stress, inflammatory markers
Target Population
Care Setting

Key Highlights

  • Lower serum zinc and MT-1 levels in stroke patients compared to controls
  • Elevated FADS1 activity index and oxidative DNA damage (8-OHdG) in stroke patients
  • Significant alterations in inflammatory markers (hs-CRP, IL-6, MDA, SOD) in stroke patients
  • Combined biomarker panel shows superior discriminative performance for stroke identification (AUC = 0.970)

Guideline-Based Recommendations

Diagnosis

  • Utilize a multidimensional biomarker panel for assessing stroke risk in elderly patients

Management

    Monitoring & Follow-up

    • Regular assessment of inflammatory and oxidative stress markers in stroke patients

    Risks

    • Increased risk of ischemic stroke associated with zinc deficiency and dysregulated FADS1 activity

    Patient & Prescribing Data

    Clinical Best Practices

      Related Resources & Content

      Original Source(s)

      Zinc homeostasis dysregulation in elderly patients with acute ischemic stroke: a multidimensional analysis integrating metallothionein, FADS1 activity, oxidative stress, and DNA integrity markers

      • by Jing Zhou, Qian Zhang, Chunmei Wang, Tingting Zhao, Tongtong Qiu, Guojie Xu, Cuiying Gu, Lihua Yu, Zhanyuan Yu

      • May 25, 2026

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