Establishment and optimization of an E. coli urinary tract infection model in Göttingen minipigs with strain recovery and characterization - Scorecard - MDSpire

Establishment and optimization of an E. coli urinary tract infection model in Göttingen minipigs with strain recovery and characterization

  • By

  • Joyce Lübbers

  • Kaila Orlandini

  • Emily Podob

  • Jeffrey Fernandez

  • Jolaine M Wilson

  • Marjolein van Heerden

  • Jeroen Zeijpveld

  • Joan van Kregten

  • Peter T. Buckley

  • Germie van den Dobbelsteen

  • Kirsten L. Bair

  • May 18, 2026

  • 0 min

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Clinical Scorecard: Development and refinement of a urinary tract infection model using uropathogenic E. coli in Göttingen minipigs with strain analysis and recovery

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationSexually mature female Göttingen minipigs
Care Setting

Key Highlights

  • Importance of strain verification in UTI studies

Guideline-Based Recommendations

Diagnosis

    Management

    • Employ intraurethral challenge to study UTI treatment and vaccine efficacy
    • Monitor for polymicrobial colonization during studies

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Model can be used to assess the efficacy of vaccines and antibiotic treatments in minipigs.

        Clinical Best Practices

        • Verify bacterial strain identity using whole genome sequencing and phenotypic assessments
        • Ensure proper acclimatization of animals to reduce stress during studies
        • Utilize controlled housing conditions to maintain animal welfare
        • Use whole genome sequencing for strain verification.

        Related Resources & Content

        Original Source(s)

        Establishment and optimization of an E. coli urinary tract infection model in Göttingen minipigs with strain recovery and characterization

        • by Joyce Lübbers, Kaila Orlandini, Emily Podob, Jeffrey Fernandez, Jolaine M Wilson, Marjolein van Heerden, Jeroen Zeijpveld, Joan van Kregten, Peter T. Buckley, Germie van den Dobbelsteen, Kirsten L. Bair

        • May 18, 2026

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