Transcriptomic signatures and immune microenvironment of acute rejection after heart transplantation: an integrated bioinformatics analysis
By
Wenjun Zhou
Langjing Huang
Wenwen Tang
May 25, 2026
Clinical Scorecard: Gene Expression Profiles and Immune Landscape in Acute Heart Transplant Rejection: A Comprehensive Bioinformatics Study
At a Glance
Category Detail
Condition Acute Heart Transplant Rejection Key Mechanisms Interferon signaling, T-cell receptor signaling, chemokine pathways, antigen presentation Target Population Heart transplant recipients Care Setting Post-transplant clinical care
Key Highlights
1,032 genes differentially expressed in acute rejection vs. non-rejection samples Strong diagnostic model with AUC=0.993 for acute rejection Increased immune cell signals in rejection, including monocytic and T/cytotoxic lymphocytes Experimental validation of gene expression findings using qPCR Need for molecular profiling to complement histologic assessment in EMB Guideline-Based Recommendations
Diagnosis
Endomyocardial biopsy (EMB) with histologic evaluation is the standard for diagnosing acute rejection. Management
Molecular profiling may provide complementary insights to histology in assessing graft rejection. Monitoring & Follow-up
Regular assessment of gene expression profiles may aid in early detection of rejection. Risks
Acute rejection can lead to decreased graft function and chronic allograft vasculopathy. Patient & Prescribing Data
Heart transplant patients undergoing EMB for rejection assessment
Molecular profiling may enhance risk stratification and management of rejection.
Clinical Best Practices
Integrate molecular profiling with histologic evaluation for comprehensive rejection assessment. Utilize gene expression patterns to inform clinical decision-making in transplant care. Related Resources & Content
