Multidisciplinary team care and outcomes in FNCLCC grade 3 soft tissue sarcoma: a propensity score–matched and weighted cohort study
By
Zhangfu Li
Xinyu Li
Baicheng Yang
Xiaoyang Li
Luqiang Wang
Ting Liu
Xinxin Zhang
Zhenguo Zhao
Libin Xu
Helin Feng
Zhenfeng Li
Shengji Yu
June 10, 2026
Clinical Scorecard: Outcomes of FNCLCC Grade 3 Soft Tissue Sarcoma with Multidisciplinary Team Management: A Propensity Score-Matched Cohort Analysis
At a Glance
Category Detail
Condition FNCLCC Grade 3 Soft Tissue Sarcoma Key Mechanisms Multidisciplinary team (MDT) care associated with lower local recurrence rates. Target Population Adults with pathologically confirmed FNCLCC grade 3 STS. Care Setting Department of Orthopaedics, Cancer Hospital, Chinese Academy of Medical Sciences.
Key Highlights
MDT care linked to lower 3-year local recurrence (6.8% vs 21.2%). No significant difference in 3-year distant metastasis between MDT and non-MDT groups. Study utilized propensity score matching and inverse probability of treatment weighting. Guideline-Based Recommendations
Diagnosis
Accurate diagnosis and risk stratification are essential for STS management. Management
Curative-intent management should involve precise evaluation, surgical planning, and multimodality treatment. Monitoring & Follow-up
3-year local recurrence and distant metastasis should be monitored post-treatment. Risks
High-grade STS has substantial risks of local recurrence and distant metastasis. Patient & Prescribing Data
Adults with FNCLCC grade 3 STS treated between 2010 and 2022.
MDT care is associated with improved local control but not with significant reduction in distant metastasis.
Clinical Best Practices
Implement MDT care for treatment planning in high-grade STS. Ensure adherence to clinical practice guidelines for sarcoma management. Related Resources & Content
