Evaluation of the CIB1R peptide derived from the cytoplasmic domain of neprilysin on cell migration in an in vitro model of lung cancer - Scorecard - MDSpire

Evaluation of the CIB1R peptide derived from the cytoplasmic domain of neprilysin on cell migration in an in vitro model of lung cancer

  • By

  • Carlos Alejandro Martínez-Armenta

  • Horacio Almanza-Reyes

  • Leslie Patrón-Romero

  • Adriana Sampayo-Reyes

  • Juan M. Alcocer-González

  • Reyes Tamez-Guerra

  • Cristina Rodríguez-Padilla

  • Humberto Antonio Salazar-Sesatty

  • Omar Zardain-Medlich-Ducoulombier

  • Francisco González-Salazar

  • Javier Vargas-Villarreal

  • June 23, 2026

  • 0 min

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Clinical Scorecard: Assessment of the CIB1R Peptide from Neprilysin's Cytoplasmic Domain on Lung Cancer Cell Migration in an In Vitro Setting

At a Glance

CategoryDetail
ConditionLung Cancer
Key MechanismsModulation of tumor cell migration and invasion by CIB1R peptide derived from neprilysin.
Target PopulationPatients with non-small cell lung cancer (NSCLC).
Care SettingIn vitro cellular model.

Key Highlights

  • CIB1R peptide reduced cell migration and invasion in A549 cells.
  • Effects were dose-dependent without significant impact on cell viability.
  • Similar inhibitory effects observed with related peptides, indicating non-sequence-specific activity.
  • Strong cell-associated fluorescence signals were noted for all peptides.
  • No significant increase in membrane permeability detected.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

        Risks

          Patient & Prescribing Data

          Patients with advanced metastatic non-small cell lung cancer.

          CIB1R and related peptides may influence tumor progression through modulation of cellular behaviors.

          Clinical Best Practices

          • Further studies are required to clarify the molecular basis of peptide effects.
          • Consideration of shared physicochemical properties in peptide design.

          Related Resources & Content

            Original Source(s)

            Evaluation of the CIB1R peptide derived from the cytoplasmic domain of neprilysin on cell migration in an in vitro model of lung cancer

            • by Carlos Alejandro Martínez-Armenta, Horacio Almanza-Reyes, Leslie Patrón-Romero, Adriana Sampayo-Reyes, Juan M. Alcocer-González, Reyes Tamez-Guerra, Cristina Rodríguez-Padilla, Humberto Antonio Salazar-Sesatty, Omar Zardain-Medlich-Ducoulombier, Francisco González-Salazar, Javier Vargas-Villarreal

            • June 23, 2026

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