Impact of Residential Radon Exposure on the Risks of Myocardial Infarction and Stroke in the All of Us Research Program - Scorecard - MDSpire

Impact of Residential Radon Exposure on the Risks of Myocardial Infarction and Stroke in the All of Us Research Program

  • By

  • Jiajun Luo

  • Zhihao Jin

  • Yuqing Yang

  • Ann Nguyen

  • Christopher O. Olopade

  • Habibul Ahsan

  • Jayant M. Pinto

  • Briseis Aschebrook-Kilfoy

  • December 3, 2025

  • 0 min

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Clinical Scorecard: Impact of Residential Radon Exposure on the Risks of Myocardial Infarction and Stroke in the All of Us Research Program

At a Glance

CategoryDetail
ConditionCardiovascular Diseases (CVD) related to residential radon exposure
Key MechanismsOxidative stress, endothelial dysfunction, systemic inflammation
Target PopulationAdults aged 35 and above in the USA
Care SettingCommunity-based cohort study

Key Highlights

  • Radon exposure linked to increased risk of myocardial infarction and stroke.
  • Significant associations observed at radon levels ≥ 2 pCi/L.
  • Current EPA action level of 4 pCi/L may not adequately protect against CVD risks.

Guideline-Based Recommendations

Diagnosis

  • Utilize EHR-derived diagnoses for incident myocardial infarction and stroke.

Management

  • Consider residential radon exposure in cardiovascular risk assessments.

Monitoring & Follow-up

  • Monitor radon levels in residential areas, especially in high-risk zones.

Risks

  • Increased stroke risk associated with residential radon exposure.

Patient & Prescribing Data

Participants aged 35 and older from the All of Us Research Program.

Focus on cardiovascular health and environmental risk factors.

Clinical Best Practices

  • Incorporate radon exposure history in cardiovascular disease evaluations.
  • Advocate for radon testing in homes, especially in high radon areas.

References

Original Source(s)

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