Relationship between MLH1, MSH2, MSH6, and PMS2 protein expression status and clinicopathological characteristics in colorectal cancer tissues
By
Hu, Wansheng
Hu, Xiaowei
Xie, Enyun
Wang, Yanyan
May 26, 2026
Clinical Scorecard: Association of MLH1, MSH2, MSH6, and PMS2 Protein Expression Levels with Clinicopathological Features in Colorectal Cancer Tissues
At a Glance
Category Detail
Condition Colorectal Cancer (CRC) Key Mechanisms Deficient mismatch repair (dMMR) protein deficiency Target Population Chinese colorectal cancer patients Care Setting Patients undergoing radical surgical resection
Key Highlights
22.5% of patients identified as dMMR Isolated PMS2 loss was the most common deficiency pattern (50.0%) dMMR CRCs more likely to be located in the right colon (61.1%) dMMR status linked to lower rate of lymph node metastasis (22.2%) Independent predictors of dMMR include right colon location, poor differentiation, and mucinous histology Guideline-Based Recommendations
Diagnosis
Routine IHC-based MMR testing in CRC patients Confirmatory molecular testing necessary for differentiating sporadic from Lynch syndrome-associated dMMR Management
Consider immunotherapy decisions based on MMR status Monitoring & Follow-up
Risks
Patient & Prescribing Data
Patients with primary colorectal adenocarcinoma
Molecular testing needed for Lynch syndrome screening
Clinical Best Practices
Utilize IHC to assess MMR protein expression Conduct multivariable analysis to identify predictors of dMMR Related Resources & Content
