Quantifying the anatomical variability of the proximal femur
-
By
-
Angelika Ramesh
-
Johann Henckel
-
Alister Hart
-
Anna Di Laura
-
December 19, 2025
-
Clinical Scorecard: Assessing the Anatomical Diversity of the Proximal Femur
At a Glance
| Category | Detail |
| Condition | Osteoarthritis requiring total hip arthroplasty (THA) |
| Key Mechanisms | Variability in proximal femoral morphology affects prosthetic femoral version (PFV) and fixation in cementless THA |
| Target Population | Patients undergoing cementless total hip arthroplasty for osteoarthritis |
| Care Setting | Orthopaedic surgical setting, pre- and post-operative imaging and planning |
Key Highlights
- Native femoral version (NFV) does not reliably predict prosthetic femoral version (PFV) due to anatomical variability.
- A sex-specific statistical shape model (SSM) was developed to quantify 3D morphological variability of the proximal femur pre- and post-operatively.
- Patient-specific femoral neck osteotomy guides enable accurate simulation and execution of planned osteotomy cuts.
Guideline-Based Recommendations
Diagnosis
- Use preoperative CT imaging to assess proximal femoral anatomy and plan osteotomy.
- Segment native proximal femur, post-osteotomy femur, and intramedullary canal for detailed morphological analysis.
Management
- Consider variability in femoral canal shape when selecting cementless femoral stem design.
- Use patient-specific osteotomy guides to improve accuracy of femoral neck cuts.
- Aim for prosthetic femoral version (PFV) target of 20° ± 5°, recognizing intraoperative adjustment limitations.
Monitoring & Follow-up
- Perform post-operative CT scans to evaluate reconstructed femur and stem positioning.
- Use statistical shape models to correlate anatomical variations with surgical outcomes.
Risks
- Inaccurate prediction of PFV may lead to suboptimal biomechanics and fixation.
- Limited intraoperative ability to adjust stem rotation may affect final implant orientation.
Patient & Prescribing Data
62 patients (31 male, 31 female) undergoing cementless THA with Quadra®–H stem for osteoarthritis
Despite targeting a PFV of 20° ± 5°, achieved PFV varies widely due to anatomical differences and limited rotational control during surgery.
Clinical Best Practices
- Utilize patient-specific femoral neck osteotomy guides to replicate preoperative plans accurately.
- Incorporate 3D imaging and segmentation to understand individual femoral morphology before stem selection.
- Recognize the limitations of current cementless stem designs in restoring optimal biomechanics due to anatomical variability.
References