Adiponectin and leptin levels in mothers, fetuses, and neonates with intrauterine growth restriction compared to those with appropriate gestational age - Scorecard - MDSpire
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Adiponectin and leptin levels in mothers, fetuses, and neonates with intrauterine growth restriction compared to those with appropriate gestational age
Clinical Scorecard: Levels of Adiponectin and Leptin in Mothers, Fetuses, and Newborns with Intrauterine Growth Restriction Compared to Those with Normal Gestational Age
At a Glance
Category
Detail
Condition
Key Mechanisms
Altered metabolic regulation and adipokine signaling
Target Population
Care Setting
Key Highlights
Adiponectin levels were significantly reduced in maternal and neonatal blood in IUGR.
Leptin levels were increased in umbilical cord blood but decreased in neonatal blood in IUGR.
Placental analysis showed significant downregulation of ADIPOQ and altered expression of LEP and WFS1 in IUGR.
Increased DNA methylation of ADIPOQ and LEP genes was observed in placental tissue in IUGR.
Guideline-Based Recommendations
Diagnosis
IUGR is diagnosed based on ultrasonographic evidence of fetal growth below the 10th percentile.
Management
Monitor maternal and fetal health closely in pregnancies diagnosed with IUGR.
Monitoring & Follow-up
Evaluate adipokine levels and placental function in IUGR cases.
Risks
IUGR is associated with heightened risks of perinatal complications, mortality, and long-term health issues.
Patient & Prescribing Data
Pregnant women with IUGR and their newborns
Clinical Best Practices
Conduct regular monitoring of fetal growth and maternal health in at-risk pregnancies.
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